4H-1-Benzopyran-4-one, 2-[(1S)-1-[4-amino-3-[3-fluoro-4-(1-methylethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)-
TGR-1202
CAS: 1532533-67-7
Molecular Formula: C31H24F3N5O3
4H-1-Benzopyran-4-one, 2-[(1S)-1-[4-amino-3-[3-fluoro-4-(1-methylethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)- - Names and Identifiers
4H-1-Benzopyran-4-one, 2-[(1S)-1-[4-amino-3-[3-fluoro-4-(1-methylethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)- - Physico-chemical Properties
| Molecular Formula | C31H24F3N5O3 |
| Molar Mass | 571.55 |
| Solubility | 10 mM in DMSO |
| Storage Condition | -20℃ |
| In vitro study | TGR-1202 to PI3Kα, β, γ, δ, the selectivity of PI3Kδ is higher. TGR-1202 inhibits the proliferation of human whole blood CD19 cells with an IC50 in the range of 100-300 nM. Treatment of PBMC by TGR-1202(RP5264) will result in G2/M phase arrest followed by an increase in the number of cells in phase sub-G0. Cell viability experiments showed that the compound would cause significant growth inhibition of immortalized leukemia cells and primary leukemia cells, with inhibition of Akt phosphorylation. |
| In vivo study | TGR-1202(RP5264) in rodents, has good oral absorption capacity, favorable pharmacokinetic properties. In vivo safety was good. |
4H-1-Benzopyran-4-one, 2-[(1S)-1-[4-amino-3-[3-fluoro-4-(1-methylethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.75 ml | 8.748 ml | 17.496 ml |
| 5 mM | 0.35 ml | 1.75 ml | 3.499 ml |
| 10 mM | 0.175 ml | 0.875 ml | 1.75 ml |
| 5 mM | 0.035 ml | 0.175 ml | 0.35 ml |
Last Update：2024-01-02 23:10:35
![4H-1-Benzopyran-4-one, 2-[(1S)-1-[4-amino-3-[3-fluoro-4-(1-methylethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)-](http://res.chembk.com/assets/images/structure/HY-12279.gif)
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Product Name: TGR-1202 Visit Supplier Webpage Request for quotationCAS: 1532533-67-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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